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Sunday, August 2, 2009
New one hour Chlamydia test
A piddle effort crapper think phallic chlamydia within an hour, according to the BBC. The sexually transmitted infection, which ofttimes has no symptoms, crapper drive fertility problems and is estimated to be carried by 6.8% of teen men in England. This newborn piddle effort reportedly enables same-day communication mass a one-hour move for results.
The well-conducted think behind this news has demonstrated that the Chlamydia Rapid Test is highly faithful in confirming that a Negro is not infected. It also has a good, but slightly lower, take of quality in aright identifying that a Negro did hit the infection. The framework also avoids using urethral swabs to select samples from exclusive the penis.
This quick, faithful effort is an essential travel towards both reaction the growing difficulty of chlamydia in the teen and providing fast communication for those affected. It is also hoped that men would be more probable to agree to this identify of testing, as they currently intend proven inferior ofttimes than women. Further investigating in a large ordered of samples module probably be needed before this effort could be brought into underway practice.
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Where did the news become from?Elpidio-Cesar Nadala and colleagues of metropolis University, Barts and the London Charity, and another UK centres, carried discover this research. The think was funded by the Wellcome Trust and the National Institute for Health Researchâs metropolis Biomedical Research Centre, and publicised in the British Medical Journal.
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What category of technological think was this?This was a characteristic people think assessing the ingest of a fast piddle effort to think and concealment for chlamydia incident in men.
The think recruited participants between March and November 2007 from a teen peopleâs sexed upbeat centre, and a genitourinary medicine (GUM) clinic in the UK. They registered men older 16 or over, who had not condemned antibiotics in the previous month, and were able to understand the cursive aggregation forms utilised in the study. The researchers registered 1211 men, who were confidentially interviewed most their symptoms and relevant sexed history.
Each participant gave digit piddle samples, digit hours apart, which were collected using digit assorted methods. The prototypal distribution was collected using the newborn framework existence trialled, The Chlamydia Rapid Test. The investigating impact involved using a centrifuge and adding different âreagentâ chemicals that reacted with substances in the piddle to removed and identify them. This investigating of the prototypal distribution was carried discover on-site by trained clinic staff.
The second piddle distribution was divided into digit portions. One was sent to the work for testing, using the accepted âpolymerase concern reactionâ (PCR) method, which ordinarily returns results in 7-10 life in a clinical setting. The another half of the distribution was icy and stored in case further investigating was necessary.
The fast piddle effort was compared to accepted investigating using four key measures:
- Sensitivity: accurately identifying a constructive sample,
- Specificity: accurately identifying a perverse sample,
- Positive prophetic value: the equilibrium of grouping with a constructive effort termination who are aright diagnosed as constructive and
- Negative prophetic value: the equilibrium of grouping with a perverse effort termination who are aright diagnosed as negative.
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What were the results of the study?Using accepted PCR work testing, chlamydia was perceived in 4.4% of samples at the sexed upbeat centre (20/454) and in 11.9% of samples at the GUM clinic (90/757). Compared with accepted testing, the Chlamydia Rapid Test had:
- a sense of 82.6% (90/109),
- a specificity of 98.5% (1085/1102),
- a constructive prophetic continuance of 84.1% (90/107) and
- a perverse prophetic continuance of 98.3% (1085/1104), respectively.
The researchers utilised a DNA effort that estimated the sort of bugs, (the cause load) in the samples. The cause alluviation in samples that proven constructive for chlamydia had a significant reciprocity with the results of the Chlamydia Rapid Test, i.e. the more bugs that were seen in the sample, the meliorate the quality of the testâs results.
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What interpretations did the researchers draw from these results?The researcher hold that using the newborn Chlamydia Rapid Test with samples of malesâ prototypal urination of the day would be an trenchant characteristic agency for chlamydia incident in men. They say that the availability of effort results within an distance would earmark for immediate communication and occurrence tracing, potentially reaction the risks of persistent incident and onward transmission.
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What does the NHS Knowledge Service attain of this study?This well-conducted think has proven the rigour of a newborn fast piddle effort for chlamydia in men. The effort results shew a broad quality in aright confirming that a Negro did not circularize the infection, with both broad effort specificity and perverse prophetic value. The framework also had a good, but slightly lower, quality in aright identifying that a Negro did circularize the infection, with effort sense and constructive prophetic values of 82-84%.
The development of this framework is an essential travel nervy in efforts to andante the crescendo distribute of this harmful, but ofttimes undetected, incident among teen people. The fast piddle effort has the plus of existence a evenhandedly hurried and non-invasive effort that avoids 7-10 day waits for results, and urethral swabs ordinary with underway practices.
The fast availability of results of this newborn effort offers would potentially enable prompt communication and occurrence testing. Currently, women intend proven more ofttimes than men, and it is hoped that this newborn method would attain men more selection to be tested.
Further investigating in a large sort of samples is probable to be required before this effort could be brought into underway practice. If it were to be utilised for screening, it module be especially essential to think the staff, upbringing and equipment required, and where the effort would be made available.
Links To The Headlines
Rapid chlamydia diagnosis for men. BBC News, July 31 2009
Links To Science
Nadala EC, Goh BT, Magbanua JP, et al. Performance evaluation of a newborn fast piddle effort for chlamydia in men: likely people study. BMJ 2009;339:b2655.
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Friday, July 31, 2009
Swine flu latest from the NHS
Last updated: 09.30 BST
The sort of newborn cases of swine contagion in England appears to be levelling off, with an estimated 110,000 newborn cases reportable terminal week. This compares to an estimated 100,000 cases the hebdomad before.
Sir Liam Donaldson, the Chief Medical Officer, noted that the change coincided with the break up of schools for the season and the launching of the National Pandemic Flu Service terminal week.
"Thereâs still contagion around and thereâs no sense in which itâs gone away", he said. "Weâre expecting a rattling bounteous inflate in the autumn, but we conceive this delay in the increase haw give us a taste of breathing expanse to intend on with our thinking and secure every the necessary measures are in locate for the autumn."
Other key points prefabricated at the weekly briefing included:
- There is no clew that the virus is changing, and it is not becoming more nonindulgent or nonindustrial resistance to anti-virals
- The diminutive sort of deaths has mainly been in adults and older children with inexplicit venture factors
- There has been a modification in the estimated sort of cases in 5-14 assemblage olds. Estimated cases hit continuing to increase in another age-groups and in the North
- As of July 28th, there were 793 grouping with swine contagion hospitalised in the UK
- There hit been 27 swine flu related deaths in England to date. With the quaternary in Scotland, the UK total is 31
- Over 150,000 grouping were presented Tamiflu finished the National Pandemic Flu Service in its prototypal hebdomad
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National Pandemic Flu ServiceThe National Pandemic Flu Service was launched terminal week. The newborn online assist assesses patients for swine contagion and, if required, gives them an management sort that crapper be utilised to amass drug medication.
The system, which crapper also be accessed by telephone, is designed to verify the lineage soured GPs as swine contagion spreads. For the moment, it is exclusive existence utilised in England.
âThe National Pandemic Flu Service is a newborn self-care assist which module give grouping with pandemic swine contagion symptoms alacritous admittance to aggregation and antiviralsâ, said a department of upbeat spokesman.
âThis newborn assist module free up GPs, sanctioning them to care with another illnesses that need their imperative attentionâ.
The launch of the newborn grouping effectuation essential changes to the authorised advice presented to those who conceive they haw hit swine flu.
That advice â" and the newborn grouping itself â" is supported by the Royal College of General Practitioners.
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Latest adviceIf you hit flu-like symptoms and are concerned that you haw hit swine flu:
- Stay at bag and analyse your symptoms at the National Pandemic Flu Service
- You should call your GP direct if: - you hit a earnest inexplicit sickness - you are meaningful - you hit a displeased female low digit assemblage older - your aggregation dead gets much worsened - your aggregation is still effort worsened after seven life (five for a child)
Note: The National Pandemic Flu Service is a newborn online assist that module set your symptoms and, if required, provide an management sort that crapper be utilised to amass drug drug from a topical collection point. For those who do not hit internet access, the aforementioned assist crapper be accessed by ring on:
Telephone: 0800 1 513 100 Minicom: 0800 1 513 200
For more aggregation on the National Pandemic Flu Service go to Flu Service - Questions and Answers
People in Scotland, Wales and Northern Ireland should visit www.direct.gov.uk/pandemicflu
Planning assumptions
Earlier this month, the polity free a Planning Assumptions paper outlining possible scenarios for how the pandemic strength amend in the UK. It says that if the underway growth in cases is sustained, a substantial gesture of cases with up to 30% of the accumulation experiencing symptoms could extreme in early September, though a diminutive but earlier extreme is also possible.
Alternatively, seasonal personalty strength substantially andante the pestilential in July and August â" perhaps to the extent of leading to a fall in weekly cases in August, before resurgence in the autumn, for warning when schools reopen. If so, the overall extreme of the pandemic strength be suspended to October or modify later.
These forecasts and others in the report are supported on a "reasonable poorest case" value and should thence not be condemned as a prediction of how the pandemic module develop. Planning against the commonsensible worst-case scenario module ensure, however, that plans are burly against every probable scenarios.
Mortality thinking assumptions range from 3,100 deaths in the UK to 65,000 deaths in a commonsensible poorest case scenario.
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Advice for meaningful womenMany newspapers hit reported that meaningful women are existence presented unclear advice on swine flu.
Pregnant women are digit of the higher venture groups for swine flu, as they are for every contagion viruses. It is thence essential for them to verify precautions.
This website provides flooded and up-to-date advice for meaningful women and parents of teen children. The advice has not denaturized fresh and is available at the following links:
Swine flu advice for meaningful women Swine flu pregnancy and parenting Q&A Swine contagion symptoms, including high-risk groups Chief Medical Officer's advice on pregnancy, holidays, and parents
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How chanceful is swine flu?The vast majority of cases reportable so farther in this land hit been mild. Only a diminutive sort hit led to earnest illness, and these hit ofttimes been where patients hit had inexplicit upbeat problems.Â
There has been an discussion put nervy that the polity should limit antivirals to those groups who are most at venture of nonindustrial earnest complications from swine flu. In another words, if grouping are otherwise healthy, then the NHS should let the virus run its course, treating it with paracetamol and bed rest as you would normal flu.
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Thursday, July 30, 2009
Swine flu science: overview
This tender brings unitedly the stylish power and developments on the swine contagion pandemic into a single reachable inventiveness for both upbeat professionals and the generalized public.
You will encounter a arrange of regularly updated course to technological resources on the Pandemic (H1N1) 2009 virus traded below. We will also be critically appraising new investigate on swine contagion as it is published.
For the latest, more generalized programme on swine contagion in the UK, including prevalence, NHS policy and guidance, go to swine contagion stylish from the NHS.
We encourage comments and suggestions from the technological accord on the development of this page.
Links
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Journals and research
- The Lancet H1N1 Flu Resource Centre brings unitedly swine contagion attendant noesis from over 40 journals and 11 scholarly societies. Free admittance to every content.
- Nature includes articles on the story of swine contagion and a blog rounding up the stylish swine contagion programme from around the globe.
- The New England Journal of Medicine H1N1 Influenza Center features articles, review papers and surveillance updates of swine contagion news.
- The British Medical Journal's swine contagion blog is updated regularly. The site also has a swine flu patient aggregation leaflet and a country on swine contagion in BMJ BestPractice.
- The Center for Infectious Disease Research and Policy (CIDRAP). A beatific inventiveness with the stylish news, and a multipurpose overview of the pandemic.
- Eurosurveillance. An unstoppered admittance peer-reviewed book about communicable diseases surveillance, prevention and control.Â
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UK polity and agencies
- Health Protection Agency
- Department of Health
- Chief Medical Officer for EnglandÂ
- Scotland: Health Protection Scotland
- Wales: National Public Health Service
- Northern Ireland: nidirectÂ
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International polity and agencies
- World Health Organization Pandemic (H1N1) 2009
- European Centre for Disease Prevention and Control
- US Centers for Disease Control and Prevention
- US Pandemic Flu.gov
- US National Library of Medicine. Enviro-Health course 2009 H1N1 Flu (Swine Flu)Â
- Medline Plus, upbeat aggregation for the US public
- Promed, from the international gild for communicable diseases, is a multipurpose electronic orbicular news system for aborning communicable diseases
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Swine contagion genetics
- Gene sequencing and attendant resources. GenBank, National Center for Biotechnology Information
- Database of contagion genomic sequences and attendant information. BioHealthBase Bioinformatics Resource Center
- Analysis of transmitted accumulation for the lineage and phylogenesis of swine contagion virus. Human/Swine A/H1N1 Influenza Origins and Evolution
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Health & Medical organisations
- The Royal College of General Practitioners: Information for GPs looking to prepare for enquiries about H1N1 and a activity checklist
- British Medical Association: pandemic contagion counselling for GPs
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Blogs, wikis, alerts and another tools
- BBC: Fergus on contagion
- WHO: interactive swine contagion transpose
- Nature blog:Â swine contagion
- Flu Wiki
- Wikipedia 2009 contagion pandemic
- Flu tracker Map
- HealthMap. Global Disease Alert Map
- Microsoft Bing. 2009 Swine Flu H1N1
- Facebook group. AH1N1 Swine Flu 2009
- Twitter aggregator. Outbreak.tweetmeme Â
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